What is Augmentin?
Augmentin is a prescription antibiotic used to treat a variety of bacterial infections, such as pneumonia, ear infections, bronchitis, urinary tract infections and skin infections.
Important information when using Augmentin medicine
You should not use Augmentin if you have severe kidney disease, if you have had liver or jaundice problems when taking amoxicillin and potassium clavulanate, or if you are allergic to any antibiotic penicillin or cephalosporin, such as Amoxil , Ceftin, Cefzil, Moxatag, Omnicef, and others.
If you switch from one tablet format to another (regular release or extended tablet), only sample the new tablet and the strength specified for you. Amoxicillin and clavulanate may not be effective or may be harmful if you do not use the exact medication form that your doctor has prescribed.
Amoxicillin and clavulanate potassium can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Augmentin can make birth control pills less effective. Ask your doctor about using non-hormonal birth control methods (such as condoms, diaphragms, spermicide) to prevent pregnancy while taking amoxicillin and clavulanate potassium.
Pharmacology of the drug Augmentin
Pharmacological group: Combination of penicillin, inc. beta-lactamase inhibitors; ATC Code: J01CR02.
Mechanism of action
Amoxicillin is a semi-synthetic penicillin (beta-lactam antibiotic) that inhibits one or more enzymes (commonly called penicillin binding proteins, PBPs) in the pathway of biosynthesis of peptidoglycan, which is a non-structural component. integral of bacterial cell walls. Inhibition of peptidoglycan synthesis leads to impairment of cell wall, usually followed by cell lysis and death.
Amoxicillin is easily degraded by beta-lactamase produced by resistant bacteria and therefore, the activity spectrum of amoxicillin does not include organisms producing these enzymes.
Clavulanic acid is a beta-lactam with a structure related to penicillin. It inactivates some beta-lactamase enzymes thus preventing inactivation of amoxicillin. Clavulanic acid alone has no clinically useful antibacterial effect.
Pharmacokinetic / pharmacodynamic relations
Time above the minimum inhibitory concentration (T> MIC) is considered the main determinant of the effectiveness of amoxicillin.
Mechanism of resistance
The two main mechanisms of amoxicillin / clavulanic acid resistance are:
Inactivated by bacterial beta-lactamases which are themselves not inhibited by clavulanic acid, including types B, C and D.
Change PBPs, reduce the affinity of antibacterial agent towards the target.
Bacterial impermeability or the pumping mechanism can cause or contribute to antimicrobial resistance, especially in gram-negative bacteria.
Augmentin drug interaction
Drug interactions can change the way your medications work or increase your risk of serious side effects. This document does not contain all possible drug interactions.
Keep a list of all products you use (including prescription / over-the-counter medicines and herbal products) and share them with your doctor and pharmacist. Do not start, stop or change the dosage of any medicine without your doctor's approval.
Products that may interact with this medication include: methotrexate.
This medication may interfere with certain laboratory tests (including certain urine glucose tests), which may cause false test results. Make sure laboratory staff and all your doctors know you use this medicine.
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