Abstract: ACE2, as the cellular receptor for SARS-CoV-2, has been an important part of many related research. Empowered by leading technology and years of experience, Creative Diagnostics has released various ACE2 products including human ACE2 stable cell line.
With COVID-19 rapidly spreading globally, scientists all over the world are devoted to related researches, trying to find an effective vaccine or drug to stop this epidemic. Angiotensin-converting enzyme 2 (ACE2) is an integral membrane protein with considerable homologous to ACE, which belongs to the peptidase M2 family. In case of human coronaviruses SARS and HCoV-NL63 infections, ACE-2 serves as a functional receptor for the spike glycoprotein of both coronaviruses.
To advance global SARS-CoV-2 researches, Creative Diagnostics has introduced a variety of ACE2 products, including human ACE2 stable cell line, human ACE2 peptide, human ACE2 blocking peptide, recombinant mouse ACE2 protein, biotinylated recombinant human ACE2 protein, etc.
Human ACE2 stable cell line at Creative Diagnostics is constructed by transduction of human ACE2 into HEK293T cells, followed by stable cell selection. HEK293T is derived from HEK293 and is commonly used in scientific research. HEK293T-human ACE2 cell line can be used for in vitro screening and characterization of drug candidates against SARS-CoV and SARS-CoV-2.
“We provide first-class human ACE2 stable cell line and hope this product can facilitate research on the novel coronavirus,” said a senior scientist at Creative Diagnostics. “We provide detailed instructions to clients to work safely with our products, such as using pipette aids to prevent ingestion and keeping aerosols down to a minimum. They will also be reminded that all waste should be considered hazardous and all liquid waste should be disposed and treated with bleach. ”
Creative Diagnostics also provides recombinant mouse ACE2 protein which migrates as 90-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. Mouse ACE2, His Tag is expressed from HEK293 and contains AA Gln 18 - Thr 740. This protein carries a polyhistidine tag at the N-terminus. It is available at the size of 50ug or 1mg.
Supported by in-house scientists and first-in-class technological platform, Creative Diagnostics has been dedicated to providing contract biologic R&D and manufacturing services as well as a variety of products. During this special period, Creative Diagnostics unveils varied products including selected antibodies, proteins and detection kits supported by detailed data as well as services such as SARS-CoV-2 pseudovirus neutralization assay.
Detailed information can be found on https://www.creative-diagnostics.com/.
About Creative Diagnostics
Creative Diagnostics is a leading manufacturer and supplier of antibodies, viral antigens, innovative diagnostic components and critical assay reagents. It also provides contract biologic R&D and manufacturing services to the diagnostic manufacturers for the biopharmaceutical market. It aims to provide a trusted source for all researchers’ assay development and manufacturing needs.