Boris Johnson will hold a press conference on Monday at 5pm, as England marks the lifting of most Covid restrictions.
But the briefing will not be in Downing Street as usual, as the prime minister self-isolating at his official country residence at Chequers.
Johnson will be joined Patrick Vallance, the chief scientific adviser and Jonathan Van-Tam, the deputy chief medical officer.
Johnson was pinged by NHS Test and Trace over the weekend after coming into contact with health secretary Sajid Javid, who subsequently tested positive for the virus.
The prime minister had initially attempted to use an opt-out to avoid having to isolate.
But he was forced into a hasty u-turn amid an angry public backlash at the idea the PM should receive special treatment.