What is Efferalgan 500mg?fferalgan 500 with the main ingredient paracetamol is effective in relieving pain and reducing fever. So far the mechanism of action at the molecular level of this activity is unknown.With this mechanism of action, Efferalgan 500 is used to treat symptoms of headache, osteoarthritis, toothache, cold and fever.Efferalgan is formulated in various forms and content, specifically as follows:Efferalgan suppositories with a content of 80 mg.Efferalgan suppositories with a content of 150 mg.Effervescent tablet 500 mg;Syrup form 30 mg / mlPharmacology of the drug Efferalgan 500mgPharmacodynamic propertiesATC Code: NO2B EO1Paracetamol is an effective analgesic and antipyretic. The drug has no effect on the cardiovascular and respiratory systems, and it does not cause stomach irritation or bleeding like salicylates.Pharmacokinetic propertiesParacetamol is easily absorbed from the gastrointestinal tract with peak plasma concentrations occurring after 30 minutes to 2 hours after ingestion. It is distributed in most body tissues; It crosses the placenta and is present in breast milk. Paracetamol is metabolized in the liver and excreted in the urine mainly as a glucuronide and sulphate complex. Less than 5% is excreted unchanged as paracetamol.A small hydroxylated metabolite is usually produced in very small quantities by mixed functional oxyases in the liver and is usually detoxified by combining with liver glutathione, which can accumulate after paracetamol overdose and cause liver damage.Side effects of Efferalgan medicine 500mgSome of the side effects that Efferalgan may cause include:DiarrheaIncreased sweatingAnorexiaNauseaStomach pain or crampsPain and swelling in the upper abdomen.There are also some other dangerous and rare side effects such as: black or bloody stools, cloudy or bloody urine.