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Solid preparations for oral administration for children have the advantages of convenient carrying and good stability, but for children, they are prone to dysphagia.
Solubilization technologyAt present, most of the methods for improving the solubility of drugs on the market are mainly drug solubilization methods, including ①pH adjustment method: suitable for some weakly acidic and weakly basic drugs, by adjusting the pH value to increase the solubility of the drug; ②mixed solvent method: add a certain proportion of organic solvents (ethanol, glycerol, ethylene glycol, polyethylene glycol, etc.)
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In December 2015, a dry suspension of aprepitant was developed by a pharmaceutical company for pediatric patients from 6 months to 12 years old and was approved by the FDA for marketing.
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