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Firstly, you have to shut down all the Apple apps.
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Thereafter, detach the USB cord from both devices.
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Now reboot both devices and connect them again.
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Now, attempt to run the backup once again to look at whether the problem has been fixed or not.
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You have to update firewall, antimalware or antivirus apps to the newest builds.
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Then add the following directories into the list of exclusion of the firewall, antimalware or antivirus settings:
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C:\Program Files (x86)\Common Files\Apple
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C:\Program Files\Common Files\Apple
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Don’t forget to unblock the YSloader.exe by all of the security apps.
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Try creating a backup.
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If that does not help, temporarily turn off the firewall and antivirus.
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In case you are utilizing an antimalware such as Malwarebytes and then turn it off.
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Moreover, turn it off ransomware protection of Malwarebytes.
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Later, check whether the issue is fixed.
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You have to detach the mobile through the system then reboot the devices.
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Thereafter, launch the Settings of the iPhone and then select the General option.
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Then select the Reset option then choose the Reset Location & Privacy option.
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You should connect the phone again with the PC and when you are asked whether you trust the device, select the Trust button.
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Firstly, close the iTunes application on PC and detach the mobile from the system.
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After that, put the mobile on charging then connect it to the Wi-Fi network.
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You should launch the Settings of the phone and then select the Apple ID option.
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Later, choose the iCloud option then select the iCloud Backup option.
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Now, select the button of Backup Now then wait to finish the backup procedure.
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Once you finish the procedure, launch the Settings of the mobile, then select the General option.
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Finally, choose the Software Update option. In case an update of the iOS is available for your device, then download it.
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Now, check whether you can create backups on your PC through iTunes.