Injectable biodegradable self-healing hydrogels have received much attention in local tumor therapy due to their ease of operation, low side effects, high drug entrapment rate, and controllable drug release capacity. However, most of the self-healing hydrogels reported so far lack the real-time loss tracer monitoring ability of self-degradation as well as the degradation therapeutic properties of tumor microenvironment response, while their biological activity needs to be further improved. Recently, Lei Bo's group at Xi'an Jiaotong University, China, developed a new class of citric acid-based bioactive hydrogel materials, which have multifunctional characteristics such as stable photoluminescence, injectable, self-repair, temperature sensitivity, and pH responsiveness, and effectively achieve non-destructive tracing ability for local microenvironment responsive therapy of tumors and degradation of self-repair materials, and the results were published in Biomaterials.
Citric acid based medical materials are an important class of biomimetic elastic bioactive materials, and are one of the few synthetic medical polymer materials approved by the US FDA for in vivo implantation. Traditional citric acid polymers have the problems of poor mechanical properties, rapid degradation, local acidity of degradation and single function, which limits the wide application in the biomedical field. In recent years, Professor Lei Bo's research group has done a lot of research work focusing on the functionalization modification and biomedical application of citrate-based polymer materials: polysiloxane-based inorganic-organic bioactive materials with multifunctional characteristics have been prepared by molecular silicification; efficient loading and controlled release of siRNA and miRNA have been achieved by cationic polymer modification for cancer therapy, bone tissue regeneration and obesity therapy; anti-infection, anti-tumor, wound tissue regeneration promotion applications have been achieved by antibacterial peptide functionalization modification; the biological effects of functionalized citrate-based polymer materials on promoting skeletal muscle regeneration through MAPK/p38 α signaling pathway have been found, as well as promoting wound tissue repair and regenerative biological effects by promoting immune cell polarization.
The multifunctional injectable polycitrate hydrogel (FPRC) recently developed by the group has the ability to visualize fluorescence tracking detection of biodegradation, as well as the responsive degradation and drug release of the tumor microenvironment, and can safely and effectively achieve local treatment of skin tumors as well as visual non-destructive tracing of material degradation. FPRC hydrogels are versatile, including temperature sensitivity, injectability, self-healing ability, photoluminescence ability and pH-responsive degradation and drug release. FPRC hydrogels have intense red fluorescence, as well as good photostability, tissue penetration and biocompatibility, ensuring that the degradation of hydrogels in vivo can be effectively tracked and detected. In addition, FPRC hydrogels have pH-responsive doxorubicin (DOX) release that effectively kills A375 cells and inhibits the growth of tumors in vivo. At the same time, compared with free DOX, FPRCDOX hydrogel has better inhibitory effect on tumor growth, and reduces the biological toxicity of DOX. These results suggest that FPRC hydrogels have good application potential in local cancer therapy, and this work provides new ideas for the real-time detection of self-healing hydrogel materials in cancer therapy.
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High blood glucose levels and hyperglycemia (or higher blood glucose ) are connected to elevated degrees of melancholy and hormone imbalance which may result in a range of chronic ailments, including diabetes.Around 29.1 million Americans have diabetes and another 86 million have been deemed pre-diabetic.
The estimated total price of diagnosed diabetes in the USA in 2012 was 245 billion.1Reduced insulin sensitivity and abnormal blood glucose control could cause:• Erectile Dysfunction• Irritability• Increased Inflammation• Hunger Cravings• Hypertension• Weight Gain• Bipolar Disorder• Poor Circulation• BlindnessPrescription medications made to boost insulin sensitivity and also regulate blood glucose, for example Metformin, may cause many undesirable side effects and might not supply a substantial clinical advantage.Common side effects of oral diabetic medications contain:2• Abdominal discomfort/pain• Nausea• Diarrhea• Lactic acid construct up/Muscle soreness• Weight gain• EdemaSugar Balance is a clinically-effective formula comprising powerful components designed to boost insulin sensitivity and improve blood glucose (sugar) control.
* The formulation involves the master antioxidant, Alpha Lipoic Acid (ALA), a rare herb, Banaba (Lagerstromeia Speciosa Leaf infusion ), and essential vitamins and trace minerals which help improve or fix the sugar signaling pathways in the body.
In 1 placebo controlled trial, subjects with 600 mg of ALA improved their insulin sensitivity by 15 percent in 28 days.3In a second analysis utilizing diabetic patients, those receiving 600 mg of ALA for 3 weeks experienced significantly reduced steps of oxidative stress in comparison to those not getting the treatment.4Banaba extract includes a chemical known as corsolic acid which has the capability to reduce glucose levels over 60 minutes of management and assist in weight control.5 In 1 study, subjects getting Banaba extract experienced a 12% reduction in fasting blood glucose and a typical 3 pounds weight loss after two weeks as a consequence of increased blood sugar control.5No adverse events have been reported in human studies utilizing Banaba supplementation, such as one study in which subjects obtained Banaba for up to a year.6Vanadium and Chromium are equally crucial trace minerals involved with carbohydrate metabolism and insulin sensitivity.
Another 6 week research utilizing 150 mcg vanadium, areas experienced a substantial improvement in their own metabolic control, such as a 20% reduction in fasting blood glucose and a 6 percent reduction in their A1c degree.81.
Borcea, V., Nourooz-Zadeh, J., Wolff, S. P., Klevesath, M., Hofmann, M., Urich, H., ... & Nawroth, P. P. (1999).
Acidity regulators are available in various forms including powder, tablets, liquids, and gels.
Some food safety organizations have proposed that the powder form is adopted as the industry standard.
The powdered form of Acidity Regulator is often used in the manufacture of nutritional supplements and food coloring and is also commonly used in the food safety testing industry.
The liquid form of Acidity Regulator can be easily used in a wide range of food applications including bakery products, bread, batters and pastries, sauces and marinades, pickles, snack foods, yogurts, teas, coffees, and teas-based beverages.
The gel form of Acidity Regulator is suitable for use as a dietary supplement for managing acidity and its effects on the human body.Other applications of Acidity Regulators in the food processing and confectionery industries include the removal of excess lactic acid produced during the emulsification process of dairy products.
This method of emulsification is often used in the production of pastries, cakes, and biscuits.
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