Iron oxide nanoparticles are iron oxide particles that are with diameters between about 1 and 100 nanometers. Their two main forms are magnetite (Fe3O4) and their oxidized form maghemite (γ-Fe2O3). Iron oxide nanoparticles can be applied in cancer magnetic nanotherapy. They are based on the magnetic spin effect in free radical reactions and the ability of semiconductor materials to generate oxygen free radicals. In addition, they can also control oxidative stress in biological media under non-uniform electromagnetic radiation.
What are iron oxide nanoparticles used for?
Nanoparticles are at the forefront of fast development in nanotechnology. They have exclusive size-dependent properties which makes these materials indispensable and superior in many areas of human activities. In recent years, iron oxide nanoparticles have demonstrated great potential in biomedical applications due to their non-toxic role in biological systems. Also, the magnetic and semiconductor properties of iron oxide nanoparticles can lead to multifunctional applications in medicine. These nanoparticles have been developed as antibacterial, antifungal, and anticancer. For cancer treatment and diagnosis, iron oxide nanoparticles have been functionalized with drugs.
How do you make iron oxide nanoparticles?
Iron oxide nanoparticles were synthesized by precipitation in isobutanol with sodium hydroxide and ammonium hydroxide. The isobutanol played a role of a surfactant in the synthesis. The nanoparticles were calcined for 100 min to 5 hours in the range of 300 to 600°C.
What are superparamagnetic iron oxide nanoparticles?
Superparamagnetic iron oxide NPs (SPIONs) are a multipurpose class of MRI-based contrast agents. These iron oxide nanoparticles have clinical uses such as in the detection of hepatocellular carcinomas and as magnetic fluid hyperthermia treatment for cancers in addition to their ability for drug magnetic targeting. Actually, SPIONs have been the most extensively studied inorganic nanocarrier systems for drug delivery. These nanocarriers are nontoxic, biodegradable, biocompatible, and efficiently cleared from the human body via the iron metabolism pathways.
About the author
As a supplier of the most comprehensive list of nanoparticles products with different sizes and surface properties, Creative Diagnostics is committed to providing a large and increasing portfolio of magnetic nanoparticles to meet any research needs. We now offer a series of Iron Oxide Nanorods (non-magnetic) with rod-shaped structure to meet our customers’ multiple requirements. These iron oxide nanorods have strong light resistance, and are non-toxic, tasteless, insoluble in alkali and slightly soluble in acid, and can be widely used in coatings, plastics, paints and pharmaceutical fields.
References
- Kostyukova, D., & Chung, Y. H. (2016). Synthesis of iron oxide nanoparticles using isobutanol. Journal of Nanomaterials, 2016.
- Abed, S. N., Deb, P. K., Surchi, H. S., Kokaz, S. F., Jamal, S. M., Bandopadhyay, S., & Tekade, R. K. (2019). Nanocarriers in different preclinical and clinical stages. In Basic Fundamentals of Drug Delivery(pp. 685-731). Academic Press.
- Hernández-Hernández, A. A., Aguirre-Álvarez, G., Cariño-Cortés, R., Mendoza-Huizar, L. H., & Jiménez-Alvarado, R. (2020). Iron oxide nanoparticles: synthesis, functionalization, and applications in diagnosis and treatment of cancer. Chemical Papers, 74, 3809-3824.
- Chee, C. F., Leo, B. F., & Lai, C. W. (2018). Superparamagnetic iron oxide nanoparticles for drug delivery. In Applications of Nanocomposite Materials in Drug Delivery(pp. 861-903). Woodhead Publishing.
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