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AI-Driven Metabolic Testing Can Help Identify Early Kidney Rejection in Post-Transplant Surveillance

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AI-Driven Metabolic Testing Can Help Identify Early Kidney Rejection in Post-Transplant Surveillance

The primary purpose of metabolic testing is to determine the metabolic condition of an individual. During a controlled environment, the testing will determine the amount of calories (food energy) and volume of oxygen consumption and output. There are three major factors that influence metabolic test results: physical activity, sleep, and food intake, and metabolism. A measurement of substrate utilization, known as substrate cycling, is used in conjunction with body composition analysis to assess changes in the energy and macronutrient balance and to identify potential dietary recommendations. A measurement of substrate to use is called bioresonance, which is a measurement of oxygen consumption and expenditure during physical activity and sleep. When multiple measurements are combined, metabolic testing can provide detailed metabolic information for an individual.

Based on measurements of biochemical and metabolic markers, test results are interpreted and compared to specific target values to determine whether the metabolic state of an individual is in a suitable state for optimal health. Resting metabolic rate is entire-body metabolism over a defined period of time, during a period of stable and strict resting conditions. This test is often used to detect excessive fat accumulation or hypoxemia and to determine the effects of nutritional status on body weight. In addition, the test is frequently employed to monitor the progression of chronic diseases, such as diabetes.

An exercise session triggers physiological responses in the body, resulting in increased heart rate, enhanced oxygen consumption, and production of neurotransmitters like dopamine and epinephrine. This enhanced oxygen consumption and metabolic response support exercise-induced energy demands during subsequent sessions. Oxygen consumption and expenditure, together with hormone release and the production and secretion of immune cells support cellular regeneration. This metabolic testing is used in patients with chronic fatigue syndrome who are treated with medication for the underlying cause of fatigue. In addition, it is used to monitor thyroid function, kidney function, protein metabolism, and inflammatory diseases such as fibromyalgia and cancer.

AI-driven metabolic testing can help identify early kidney rejection in post-transplant surveillance. In March 2021, numares AG, the NMR diagnostics company, made a 510(k) submission to the U.S. Food and Drug Administration for its AXINON IVD System, a NMR-platform for AI-driven, metabolomics-based diagnostics.

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