Microscopic Polyangiitis (MPA) Treatment Market

Market Overview

The "Global Microscopic Polyangiitis (MPA) Treatment Market" is predicted to grow at a high CAGR of 5.5% during the forecasting period (2021-2028).

Microscopic polyangiitis (MPA), known as ANCA-associated vasculitis, is a rare disorder characterized by inflammation of the blood vessels that restricts the blood flow and damage vital organs and tissues. Some other forms of ANCA-associated vasculitis include eosinophilic granulomatosis with polyangiitis (EGPA) and granulomatosis with polyangiitis (GPA). MPA mostly affects the small to medium-sized blood vessels, particularly involving the kidneys, lungs, nerves, skin, and joints. It can worsen rapidly, so early diagnosis and treatment are essential to prevent kidney or respiratory damage or organ failure.

Microscopic polyangiitis can affect both men and women of all ages, but the average age is around 50, and men may get MPA more often. MPA is rare, with prevalence at 1 to 3 cases per 100,000 people in the United States. The incidence is around 2 cases per 100,000 people in the United Kingdom and an estimated 1 case per 100,000 people in Sweden.

MPA is diagnosed by several tests including, the blood test for antineutrophil cytoplasmic antibodies (ANCA), urine test for diagnosis of red blood cells (RBCs), and imaging procedures such as computed tomography (CT), magnetic resonance (MR) scan, and X-rays. If these tests are positive for the presence of MPA, biopsy (tissue sample testing) is performed to confirm the presence of MPA.

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Market Dynamics

The global microscopic polyangiitis (MPA) treatment market growth is majorly driven by the rising development of new treatments for MPA and robust pipeline drugs. Some of the pipeline drugs for treating microscopic polyangiitis are Abatacept, IFX 1, among others. In July 2018, InflaRx N.V., a German clinical-stage bio-pharmaceutical company, received the U.S. Food and Drug Administration (FDA) approval for conducting phase II clinical trials of IFX-1 for treatment of anti-neutrophil cytoplasmic autoantibody (ANCA) vasculitis, presence of ANCA indicates that the patient is suffering from microscopic polyangiitis (MPA). IFX-1, an inhibitor of the complement system, neutralizes the C5a component without affecting the normal immune functions. Hence, increasing clinical trials for the development of new treatments for MPA is expected to boost the microscopic polyangiitis market's growth over the forecast period.

The increasing approvals by regulatory bodies such as the U.S. Food and Drug Administration (FDA), European Medicines Agency (EMA), Medicines and Healthcare products Regulatory Agency (MHRA), among others for several drugs for the treatment of MPA, is further driving the growth of the market. For instance, in October 2018, Genentech received the U.S. Food and Drug Administration (FDA) approval to update the Rituxan label to include the follow-up treatment information of adult patients suffering from granulomatosis with polyangiitis and microscopic polyangiitis (MPA), who had shown improvement in medical condition with the glucocorticoid and cyclophosphamide induction treatment.

However, the global microscopic polyangiitis market growth is hindered by some factors, including side-effects caused by the drugs. Some of the side-effects caused by corticosteroids include skin thinning and intense pain. Monoclonal antibody production involves costly and time-consuming research. Azathioprine involves side effects such as diarrhea, joint pain, loss of coordination, seizure, and vision changes.

Segment Analysis

– By Drug

·      Rituximab (Rituxan)*

·      Cyclophosphamide (Cytoxan)

·      Azathioprine

·      Prednisone

·      Avacopan

·      Others

– By Distribution Channel

·      Hospital pharmacies*

·      Retail pharmacies

·      Online pharmacies

Geographical Analysis

North American region is dominating the global microscopic polyangiitis (MPA) treatment market accounting for the maximum market share in 2019 due to the increasing development of drugs to treat MPA. In the United States, the annual incidence of microscopic polyangiitis is 3.6 cases per million persons, and the prevalence is one to three cases per 100,000 population. In September 2019, Roche received the U.S. Food and Drug Administration (FDA) approval for Rituxan® (rituximab), in combination with glucocorticoids, for the treatment of granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) in pediatric patients two years of age and older.

On the other hand, the European microscopic polyangiitis market is projected to grow at a significant CAGR over the forecast period due to increasing clinical trials and drug approval. For instance, Bristol-Myers Squibb Company is conducting phase III clinical trials for Abatacept (Orencia), which is expected to be completed by September 2022. Orencia is a recombinant protein that inhibits the T lymphocyte activation pathway, thereby suppressing the immune system.

Asia Pacific microscopic polyangiitis market is expected to grow at the fastest CAGR over the forecast period due to increasing product launches. For instance, in March 2018, American Pharmaceuticals Ltd., a China-based generic pharmaceutical company, received the US FDA approval for the Abbreviated New Drug Application (‘ANDA’) for its cyclophosphamide capsules 25mg and 50mg. Cyclophosphamide is an immunosuppressive agent for the treatment of microscopic polyangiitis in combination with corticosteroids.

Competitive Landscape

The microscopic polyangiitis (MPA) treatment market is highly competitive and consists of several major players and new players in the market. Some of the key players which are contributing to the growth of the market are ChemoCentryx Inc., Celltrion, Inc., Teijin Pharma Ltd, Sandoz International GmbH (Novartis Division), TTY Biopharm Company Ltd, Genentech, Inc., InflaRx N.V., Bristol-Myers Squibb Company, Amerigen Pharmaceuticals Limited, among others. The major players are adopting several growth strategies such as product launches, clinical trials, acquisitions, and collaborations, contributing to the growth of the microscopic polyangiitis (MPA) treatment market globally. For instance,

On 4th May 2020, Israeli generics giant Teva Pharmaceutical Industries and partner, South Korean biotechnology company Celltrion, launched their rituximab biosimilar Truxima (TL011) in the US. Truxima (rituximab-abbs) is now available in the US for the treatment of patients with non-Hodgkin’s lymphoma (NHL), chronic lymphocytic leukemia (CLL), rheumatoid arthritis, granulomatosis with polyangiitis (Wegener’s granulomatosis), and microscopic polyangiitis.

In January 2020, Pfizer announced to introduce three new biosimilars this year. The company plans to launch Avastin biosimilar Zirabev (bevacizumab-bvzr), Rituxan biosimilar Ruxience (rituximab-pvvr), and Herceptin biosimilar Trazimera (trastuzumab-qyyp). The audience is available to treat adult patients with non-Hodgkin’s lymphoma, chronic lymphocytic leukemia, and granulomatosis with polyangiitis and microscopic polyangiitis.

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