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What are the Examples of the Peptide Therapeutics in Metabolic Disorders?

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Ben Wood
What are the Examples of the Peptide Therapeutics in Metabolic Disorders?

Another approach to peptide therapeutics is to target enzymes involved in metabolic pathways. For example, dipeptidyl peptidase-4 (DPP-4) inhibitors like sitagliptin and saxagliptin can increase GLP-1 levels by inhibiting its degradation, leading to improved glycemic control in patients with type 2 diabetes.


Peptide therapeutics can also be used to target receptors involved in metabolic regulation, such as the melanocortin-4 receptor (MC4R), which plays a key role in appetite control. Agonists of MC4R like setmelanotide have shown promising results in clinical trials for rare genetic disorders like pro-opiomelanocortin (POMC) deficiency and leptin receptor deficiency, which can lead to severe obesity.


Moreover, peptides are not progressively constant, obstructing their therapeutic strength for chronic disorders where huge concentrations of therapeutics are required. Anyhow, peptides have various benefits above their small molecule equivalents. They have high empathy, selectivity, and are associatively budget friendly. They are also vastly versatile and can be personalized for particular purposes, which can raise the chances of efficacy. They can also be personalized to aim targets that are earlier regarded undruggable.


In summary, Peptide Therapeutics in Metabolic Disorders offer a promising approach to treating metabolic disorders by targeting specific molecular pathways involved in regulation of glucose and energy homeostasis. Ongoing research and development in this field may lead to new and effective therapies for these conditions.


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http://thrivearticles.weebly.com/article/peptide-therapeutics-in-metabolic-disorders-a-unique-class-of-pharmaceutical-agents-composed-of-a-series-of-well-ordered-amino-acids


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