CAR-T Cell Therapy: Advancements and Future Perspectives

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CAR-T Cell Therapy: Advancements and Future Perspectives

The Chimeric antigen receptor CAR-T cell therapy has revolutionized the immunotherapy field with its high success rate against hematological diseases. Investigations in the early 1980s conceived the idea about tumor-infiltrating lymphocytes; however, reproducibility in invitro hampered further developments. It was not until 1993 Immunologist Dr. Zelig Eshhar created the first generation of chimeric T cells at the Weizmann Institute, Israel. The first-generation was successful during experiments, although not clinically effective. Since then, over three decades, a significant chunk of scientific intellect and considerable Research in cancer immunology has optimized this technology further.

Stepping forward to 2021, we got 5 FDA-approved drugs, Diverse manufacturing platforms, an estimated billion-dollar market, and more than 250 players have invested their portfolios into generating/marketing/manufacturing CAR-T-based therapeutics. Furthermore, now CAR T-based therapies have expanded their horizon into diseases other than oncology, ranging from viral infections such as HIV, CMV to Autoimmune disorders. Ongoing COVID-19 too finds itself in soup as NCT04324996 sponsored by Chongqing Public Health Medical Centre is currently in phase 2.

However, after decades of modifications, Research & trials, the question remains about its efficacy against solid tumors, recent advancements, who are the key players developing platforms for next-generation CARs? And the next big breakthrough in this field.

The CARs Generation:

CARs are divided predominantly into three generations; however, incorporating multiple intracellular domains has made them more advanced as the next generation. The division is according to their intracellular signaling domains.

The first generation: comprise one extracellular domain (scFv) and an intracellular CD3ζ domain.

Second-generation: CARs have a unique costimulatory part derived from CD28 that significantly improved their clinical efficacy during treatment by increasing the survival of modified T lymphocytes.

The third generation: consists of molecules having three or more cytosolic costimulatory domains. In addition to CD28, 4-1BB, CD27, ICOS, OX40 can be coupled that significantly increase the activation, survival, and potency of the genetically engineered T lymphocytes. However, the second-generation CARs have shown the best clinical outcomes and safety to date.

Next-generation: Consists of One or more intracellular domains.

For the complete in-depth article on ‘CAR-T Cell Therapy’, please visit @ https://www.iebrain.com/car-t-cell-therapy-advancements-and-future-perspectives/

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CAR-T Cell Therapies Market (3rd Edition) by Target Indications by Roots Analysis

ella turner 2022-01-06

The report highlights the efforts of both industry players and academic organizations in this rapidly evolving segment of the biopharmaceutical industry. Amongst other elements, the report features the following:§ A detailed assessment of the current market landscape of drug developers engaged in the development of CAR-T cell therapies. html § To request a sample copy / brochure of this report, please visit https://www. Gene Therapy Market (4th Edition): Industry Trends and Global Forecasts, 2020-20304. Oncolytic Virus Therapy Market: Pipeline Review, Developer Landscape and Competitive Insights, 2020-2030About Roots AnalysisRoots Analysis is one of the fastest growing market research companies, sharing fresh and independent perspectives in the bio-pharmaceutical industry.

Car T Cell Therapy is expected to expand a phenomenal growth from assessment period of 2023-2030

Saya Bonde 2023-02-08

These CAR T-cells are designed to specifically target and kill cancer cells while leaving healthy cells untouched. It is important to consult with a qualified healthcare provider to determine if CAR T-cell therapy is an appropriate treatment option for you. Improving outcomes: Car T cell therapy is still relatively new, but early results are promising. Cost: Currently, Car T cell therapy is very expensive and is not covered by many insurance plans. Overall, Car T cell therapy is a rapidly developing field, with many exciting advances expected in the coming years.

CAR T-Cell therapy Market - Rising Trends, Demands and Business Outlook 2021–2031

Kanika Gupte 2022-09-09

According to a new report published by Allied Market Research, titled "CAR T-Cell Therapy Market", the car T-cell therapy market is worth $1. A major slowdown in clinical trials due to strict government guidelines against COVID-19 is hampering the growth and size of the CAR T-cell therapy market. The reduction in human travel, border closures and population lockdowns have affected the chain of life-saving pharmaceutical products in the CAR T cell therapy market. About Us:Allied Market Research (AMR) is a full-service market research and business-consulting wing of Allied Analytics LLP based in Portland, Oregon. Contact:David Correa5933 NE Win Sivers Drive#205, Portland, OR 97220United StatesUSA/Canada (Toll Free): +1-800-792-5285, +1-503-894-6022UK: +44-845-528-1300Hong Kong: +852-301-84916India (Pune): +91-20-66346060Fax: +1(855)550-5975help@alliedmarketresearch.

CAR T Cell Therapy Market Shows Strong Growth with Leading Players

nilesh 2022-01-19

The CAR T Cell Therapy Market report offers comprehensive study of the Global Market segments including target antigen and application. The global CAR T Cell Therapy Market research report presents key company profiles of organizations active across the Global Market. As the Global Market report suggests that the Global Market will register a CAGR of 42. Regional OverviewLAck of research backed information in several regions may hinder the CAR T Cell Therapy Market Market growth. The Global Market report covers all these key regions including the Middle East, Africa, Brazil, and others active in the global Global Market.

CAR T Cell Therapy Market Size, Business Revenue Forecast, Leading Competitors

nilesh 2022-04-29

As per Global Market analysts, the Global Market based companies will face certain challenges during the forecast period 2020 to 2027. The CAR T Cell Therapy Market report offers comprehensive study of the Global Market segments including target antigen and application. The global CAR T Cell Therapy Market research report presents key company profiles of organizations active across the Global Market. The Global Market report covers all these key regions including the Middle East, Africa, Brazil, and others active in the global Global Market. As the Global Market report suggests that the Global Market will register a CAGR of 42.

CAR T Cell Therapy Market Insight | Outlook | Growth Analysis Report 2022-2028

Aniqa Sheikh 2022-10-15

The report also sites the latest growth opportunities in the upcoming years. The broad CAR T cell therapy market has been sub-grouped into target antigen and therapeutic application. Request a FREE Sample Copy of CAR T Cell Therapy Market Report with Full TOC At: https://www. The key players in the CAR T cell therapy market include Bellicum Pharmaceuticals, Inc. Browse Full Global CAR T Cell Therapy Market Research Report with TOC At: https://www.

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The CAR T-Cell Therapy Market to Bear Testimony to Digitization

Jayprakash Sharma 2022-03-30

The CAR T-Cell Therapy Market is likely to grow at an impertinent level shortly. According to a recent study by Persistence Market Research, the global CAR T-cell therapy market is anticipated to experience high growth over the coming years. 1% of the global CAR T-cell therapy market, due to increasing number of life science companies focusing on the development and commercial manufacturing of CAR T-cells in the region. Many of the chief players in the CAR T-cell therapy market are focusing on product launches and collaborations for global expansion. About Us: Persistence Market ResearchContact Us:Persistence Market ResearchAddress – 305 Broadway, 7th Floor, New York City, NY 10007 United StatesU.

CAR-T Cell Therapy Treatment Market Size, Share, Trends, Massive Growth & is Expected to Reach USD 37,423.56 million & Grow 30.0% CAGR Forecast by 2028-Autolus, Atara Biotherapeutics, Inc., Amgen Inc

Smriti Somani 2022-01-10

The structured analysis offers a graphical representation and a diagrammatic breakdown of the CAR-T Cell Therapy Treatment Market by region. Increase in usage of CAR-T cell therapy for the treatment of cancer and infectious disease acting as driver for the CAR-T cell therapy treatment market growth. In 2021, autologous CAR-T cells segment is expected to dominate the CAR-T cell therapy treatment market because the drugs approved for CAR-T cell therapy are autologous in nature. In 2021, second generation CAR-T cells segment is expected to dominate the CAR-T cell therapy treatment market because the approved therapies are second generation based structure. In 2021, yescarta segment is expected to dominate the CAR-T cell therapy treatment market because yescarta is the first approved CAR-T cell therapy for oncology therapeutic class.

Overcoming The Challenges of CAR T-Cell Therapy Development

Ingenious E-Brain Solutions 2023-04-26

Immunotherapy is a treatment technique for cancer that aids your immune system in fighting cancerous cells. What Is CAR T-Cell Therapy? The treatment employs modified T cells known as chimeric antigen receptor (CAR) T-cells to recognize and kill cancer cells. A chimeric antigen receptor (CAR) is transmitted into the cells via a viral vector, allowing T cells to recognize better and destroy cancer cells. Antigen receptor cells multiply and destroy target cells as they realize the patient’s cells’ desired surface structure.

CAR T Cell Therapy: Unraveling The Long-Term Outcomes

sachin sadgir 2023-07-21

The success of CAR T Cell Therapy in achieving complete and durable remissions has been a beacon of hope for many cancer patients. Initial data from clinical trials and real-world experiences have shown that a significant proportion of patients who respond to CAR T cell therapy maintain their remissions over extended periods. Moreover, understanding the factors that contribute to treatment resistance and relapse is crucial for improving CAR T Cell Therapy long-term success. As more patients receive CAR T cell therapy and long-term data accumulates, researchers can refine treatment protocols and develop strategies to optimize long-term outcomes. Managing and mitigating these toxicities is crucial for the successful implementation of CAR T cell therapy.

The Global CAR T Cell Therapy Market Growth Accelerated By Rising Adoption Of New Therapies

Pooja Khodke 2024-01-15

The global Car T Cell Therapy Market is estimated to be valued at Us$ 12,709. This has propelled the growth of the global CAR T cell therapy market during the forecast period. Segment Analysis CAR T cell therapy market is segmented based on target antigen, application and geography. Key Takeaways The Global CAR T Cell Therapy Market Demand is expected to witness high growth during the forecast period of 2023 to 2030. The global CAR T Cell Therapy Market is estimated to be valued at US$ 12,709.

CAR T-Cell Therapy Market– Demand in Market, Share, Size, Revenue, Growth Overview, and Latest Trend 2028

researchnester.insights 2021-12-20

The market for CAR T-cell therapy is projected to grow by a CAGR of around 35% over the forecast period, i. Chimeric Antigen Receptor T-cell therapy, commonly known as the CAR T-cell therapy, is a form of immunotherapy for the treatment of cancer. On the basis of target antigen, the CAR T-cell therapy market is segmented into CD19, CD20, CD22, CD30, GD2 and others, out of which, the segments for CD19 and CD20 target antigens are anticipated to hold the largest shares in the market. com/sample-request-2441Based on region, the CAR T-cell therapy market is segmented into five major regions including North America, Europe, Asia Pacific, Latin America and Middle East & Africa region. Access Full Report, here: https://www.

Driving Towards a Cure: The Global Growth of CAR T Cell Therapy Market

Yashvi Gadhiya 2023-07-26

Among these, Chimeric Antigen Receptor (CAR) T cell therapy has emerged as a groundbreaking approach in cancer treatment. As the technology continues to advance, the global CAR T cell therapy market is experiencing unprecedented growth, driving the pursuit of a cure. The CAR T Cell Therapy Market has witnessed remarkable growth due to several factors. The global CAR T Cell Therapy Market has also benefited from the surge in investment and funding from both public and private sectors. The growth of the global CAR T Cell Therapy Market represents a monumental step forward in the fight against cancer.

CAR T cell Therapy Market Segmentation by Types, Specification and Applications 2020 to 2025

Rohit Kamble 2020-07-01

Global CAR T cell Therapy Market is projected to reach USD 8716.06 Million by 2025 at a CAGR of 58.52% during the review period from 2019 to 2025.

Chimeric Antigen Receptor (CAR) T Cell Therapy is an immunotherapy used for cancer treatment.

In this therapy, T cells from patient body are isolated and inserted in the CAR gene so that the gene for the specific receptor binds to a certain protein on the patient’s cancer cells.Growing prevalence of cancer across the world, technological advancement for advanced & reliable treatment for cancer, and rise in the number of cell therapy clinical studies are driving the growth of the global CAR T Cell Therapy market.

According to the National Cancer Institute, it is estimated that 1,735,350 new cases of cancer were diagnosed, and 609,640 deaths were reported in the US in 2018.

Moreover, the growing pharmaceutical industry is also expected to boost market growth.Get free Sample @ https://www.marketresearchfuture.com/sample_request/8102Segment AnalysisThe global CAR T cell therapy market, by target antigen, has been segmented into CD19, CD22, and others.

The CD19 target antigen segment accounted for a value of USD 342.56 million in 2018.

Anthropic AI Startup Is Fastest Growing Segment Fueling The Growth Of Car T Cell Therapy Market

Sachin Sadgir 2023-11-06

The global Car T Cell Therapy Market is estimated to be valued at US$ 12709. The number of clinical trials indicates strong research and development of CAR T-cell therapy as an emerging treatment option for various cancers. Segment Analysis The global car T cell therapy market is segmented into target antigen, manufacturing, indication, end user, and region. Regional analysis North America holds the largest share of the car T cell therapy market owing to presence of well-developed healthcare infrastructure and increasing adoption of advanced treatment options. Growing healthcare spending, rising geriatric population, and increasing investments by key players are boosting the regional market growth.

CAR-T Cell Therapy Research Key Drivers and Restraints, Regional Outlook, End-User Applicants by 2027

Devanand Patil 2021-06-30

Global CAR-T cell therapy Market: OverviewCancer is one of the leading causes of fatalities worldwide.

During the time of CAR-T cell therapy, the T-cells of a person are derived, reformed, and the put inside the body of a human being wherein the restructured cells multiply in number and then attack the cancer cells.Request Brochure – https://www.transparencymarketresearch.com/sample/sample.php?flag=B_id=64910Currently, CAR T cell therapy is considered as an extremely effective procedure for the treatment of patients suffering from blood cancer and has already been through other methods of cancer treatment such as chemotherapy.

The effectiveness of the process in treating cancer is likely to fuel growth of the global CAR-T cell therapy market in the years to come.Rising incidences of cancer across the globe together with the relentless technological advancement for reliable and effective cancer treatment is expected to favor growth of the global CAR-T cell therapy market over the period of projection, from 2019 to 2027.

The developments are likely to shape the contours of the global CAR-T cell therapy market over the assessment tenure, from 2019 to 2027.

The insights offered in the report are estimated to help the industry players and investors to make a correct assessment of the completive ecosystem and make strategies accordingly.Request COVID Analysis on CAR-T Cell Therapy Market – https://www.transparencymarketresearch.com/sample/sample.php?flag=covid19_id=64910Global CAR-T cell therapy Market: Trends and OpportunitiesRising Geriatric Population with Weakening Immune System Boost Market GrowthThe global CAR-T cell therapy market is primarily driven by increasing number of acquisitions, thanks to the augmented importance of cellular therapies.

In addition to that, some of the acquisitions are done to facilitate more innovative research and development activities, which further boosts the global CAR-T cell therapy market in near future.

Global CAR T-Cell Therapy Market to Grow at a CAGR of 44.79% from 2020-2030

bisresearch reports 2021-11-12

The market is favored by the development of CAR T-cell therapy for several clinical areas such as diffuse large B-cell lymphoma (DLBCL), acute lymphoblastic leukemia (ALL), multiple myeloma (MM), chronic lymphocytic leukemia (CLL), follicular lymphoma (FL), mantle cell lymphoma (MCL), and other cancers or indications.

The increase in the geriatric population and the increasing number of lymphoma and leukemia cases across the globe are expected to translate into a significantly higher demand for the CAR T-cell therapy market.Furthermore, the companies are investing huge amounts in research and development of CAR T-cell therapy either as a monotherapy or as combination therapy.

The clinical trial landscape of various hematologic cancers has been on the rise in recent years, and this will fuel the CAR T-cell therapy market in the futurMarket SegmentationTherapy Application – Diffuse large B-cell lymphoma (DLBCL), Acute lymphoblastic leukemia (ALL), Multiple myeloma (MM), Chronic lymphocytic leukemia (CLL), Follicular lymphoma (FL), Mantle cell lymphoma (MCL), and other cancers or indicationsTarget Antigen – CD19/CD22, BCMA (B-cell maturation antigen), and others target antigensRegional SegmentationNorth America – U.S., CanadaEurope – Germany, France, Italy, U.K., Spain, and Rest-of-EuropeAsia-Pacific – China, Japan, India, South Korea, Australia, and Rest-of-Asia-Pacific (RoAPAC)Latin America – Brazil, Mexico, and Rest-of-the-Latin AmericaRest-of-the-WorldGrowth DriversRising Number of Patients with Hematologic CancersDramatic Rise in Global CAR T-Cell TrialsLandmark Approvals of CAR T-Cell Therapies by the U.S. FDA and the EMAMarket ChallengesHigh Treatment Cost of CAR T-Cell TherapySide Effects of CAR T-Cell TherapyMarket OpportunitiesOpportunities for ImmunotherapyKey Companies ProfiledAmgen, Inc., Autolus Therapeutics plc., Bellicum Pharmaceuticals, Inc., Bluebird Bio Inc., Bristol-Myer Squibb, CARsgen Therapeutics, Ltd., Cartesian Therapeutics, Inc., Cellectis S.A., Celyad Oncology SA, Fortress Biotech, Inc., Janssen Pharmaceuticals, Inc., Kite Pharma, Inc., Legend Biotech Corporation, Novartis AG, and Pfizer, Inc.View Report - https://bisresearch.com/industry-report/car-t-cell-therapy-market.htmlKey Questions Answered in this Report:What is a CAR T-cell?How are CAR T-cells developed?What are the various indications targeted using CAR T-cell therapies?What are the various CAR T-cell therapies available in the market?What are the emerging CAR T-cell therapies for the treatment of hematologic cancers?How does the pipeline for the global CAR T-cell therapy market look like?What is the current market size and future potential of these CAR T-cell therapies?What are the major market drivers, challenges, and opportunities in the global CAR T-cell therapy market?What is the mechanism of action of various CAR T-cell therapies available in the market?What mechanisms of action and molecules are being trialed the most in pipeline products?What are the target antigens in CAR T-cell therapy?How does the clinical trial landscape look for the global CAR T-cell therapy market?What is the patent landscape of this market?

What will be the impact of patent expiry on this market?What is the price structure of CAR T-cell products?What is the total cost of treating a patient with CAR T-cell therapy?What will be the impact of COVID-19 on this market?What are the guidelines implemented by different government bodies to regulate the approval of CAR T-cell therapy?What are the reimbursement scenario and regulatory structure for CAR T-cell therapy?What are the challenges faced by manufacturers in CAR T-cell therapy development?What are the key technological developments on which the current industry leaders are spending a major share of their research and development (R) investments?Which are the leading players currently holding dominating shares in the global CAR T-cell therapy market?What are the key strategies incorporated by the players of the global CAR T-cell therapy market to sustain the competition and retain their supremacy?What is the current revenue contribution of the global CAR T-cell therapy market (by application type), and how is it expected to evolve in the forecast period?What is the current revenue contribution of the global CAR T-cell therapy market (by target antigen), and how is it expected to evolve in the forecast period?Which region is expected to contribute the highest revenue to the global CAR T-cell therapy market during the forecast period?Within the research report, the market is segmented based on application, target antigen, and region.

Each of these segments covers the snapshot of the market over the projected years, the inclination of the market revenue, underlying patterns, and trends by using analytics on the primary and secondary data obtained.Get Sample Report - https://bisresearch.com/requestsample?id=1020=download

Global CAR T Cell Therapy Market Size, Study, By Product, Application, And Forecasts 2028

Kartik Pilla 2022-12-10

Bharat Book Bureau Provides the Trending Market Research Report on “Global CAR T Cell Therapy Market & Clinical Trials Insight 2028” under the Life Sciences Market Research Report Category. The report offers a collection of superior Market research, Market analysis, competitive intelligence, and Market reports. The global CAR T cell therapy market is highly consolidated with several key players. As per our report findings, the Global CAR T cell therapy market opportunity is expected to surpass US$ 15 Billion by 2028. The report analyzes and forecasts the size of the global CAR-T cell therapy market.

CAR T-Cell Therapy: A Revolutionary Approach in Cancer Immunotherapy

naufan003 2024-03-13

Chimeric antigen receptor T-cell (CAR T-cell) therapy is an immunotherapy that utilizes the patient's own T cells to fight cancer. The CAR T cells are tested to ensure high CAR expression levels and potency against the targeted cancer cells. Target Antigens for CAR T-Cell Therapies Currently, the main antigens targeted by FDA-approved CAR T-cell therapies are CD19 and BCMA. Challenges with CAR T-Cell Therapies While CAR T-cell therapy has revolutionized cancer treatment, it is also associated with safety concerns and challenges that need to be addressed. Potential of CAR T-Cell Therapies Despite current drawbacks, CAR T-cell therapy holds promise as a promising new form of personalized cancer treatment.

Global CAR T Cell Therapy Market Analysis | Industry Report 2026

Sonam Shaha 2020-03-27

The Global CAR T Cell Therapy Market Research Report - Industry Analysis, Size, Share, Growth, Trends and Forecast Till 2026 gives an evaluation of the market developments based on historical studies and comprehensive research respectively.

The market segments are also provided with an in-depth outlook of the competitive landscape and a listing of the profiled key players.DriversThe increasing rate of incidence and prevalence for various type of cancerRestraintsHigh costThe comprehensive value chain analysis of the market will assist in attaining better product differentiation, along with a detailed understanding of the core competency of each activity involved.

The market attractiveness analysis provided in the report aptly measures the potential value of the market providing business strategists with the latest growth opportunities.The report classifies the market into different segments based on targeted antigens, and application.

These segments are studied in detail incorporating the market estimates and forecasts at the regional and country level.

The segment analysis is useful in understanding the growth areas and probable opportunities of the market.Browse the complete Global CAR T Cell Therapy Market Research Report - Industry Analysis, Size, Share, Growth, Trends and Forecast Till 2026 @ https://www.decisiondatabases.com/ip/20786-car-t-cell-therapy-market-reportThe report also covers the complete competitive landscape of the global CAR T Cell Therapy market with company profiles of key players such as:Bellicum Pharmaceuticals, Inc.Celgene CorporationCellectisJuno TherapeuticsKite Pharma Inc.Novartis International AGA detailed description of each has been included, with information in terms of H.Q, future capacities, key mergers & acquisitions, financial overview, partnerships, collaborations, new product launches, new product developments, and other latest industrial developments.SEGMENTATIONS IN THE REPORT:By Targeted Antigens:CD 19CD 20GD2CD22CD30CD33HER1HER2MesoEGFRvlllOthersBy Application:Acute Lymphocytic LeukemiaChronic Lymphocytic LeukemiaNon Hodgkin LeukemiaMultiple MyelomaPancreatic CancerNeuroblastaBreast CancerAcute Myeloid LeukemiaHepatocellular CarcinomaColorectal CancerOthersBy Geography:North America (NA) – US, Canada & Rest of North AmericaEurope (EU) – UK, Germany, France & Rest of EuropeAsia Pacific (APAC) – China, Japan, India & Rest of APACLatin America (LA) – Brazil & Rest of Latin AmericaMiddle East & Africa (MEA) – the Middle East and AfricaDownload Free Sample Report of Global CAR T Cell Therapy Market @ https://www.decisiondatabases.com/contact/download-sample-20786The Global CAR T Cell Therapy Market has been exhibited in detail in the following some chapters -Chapter 1 CAR T Cell Therapy Market PrefaceChapter 2 Executive SummaryChapter 3 CAR T Cell Therapy Industry AnalysisChapter 4 CAR T Cell Therapy Market Value Chain AnalysisChapter 5 CAR T Cell Therapy Market Analysis By Targeted AntigensChapter 6 CAR T Cell Therapy Market Analysis By ApplicationChapter 7 CAR T Cell Therapy Market Analysis By GeographyChapter 8 Competitive Landscape Of CAR T Cell Therapy CompaniesChapter 9 Company Profiles Of CAR T Cell Therapy IndustryPurchase the complete Global CAR T Cell Therapy Market Research Report @ https://www.decisiondatabases.com/contact/buy-now-20786Other Reports by DecisionDatabases.com:Global Plasma Therapy Market Research Report - Industry Analysis, Size, Share, Growth, Trends and Forecast Till 2026Global Radiation Therapy Market Research Report - Industry Analysis, Size, Share, Growth, Trends and Forecast Till 2026Global Testosterone Replacement Therapy Market Research Report - Industry Analysis, Size, Share, Growth, Trends and Forecast Till 2026About-Us:DecisionDatabases.com is a global business research reports provider, enriching decision makers and strategists with qualitative statistics.

DecisionDatabases.com is proficient in providing syndicated research report, customized research reports, company profiles and industry databases across multiple domains.Our expert research analysts have been trained to map client’s research requirements to the correct research resource leading to a distinctive edge over its competitors.