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EULAR 2022: A sneak peek at UCB’s Bimekizumab abstract presentations

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Michael
EULAR 2022: A sneak peek at UCB’s Bimekizumab abstract presentations
UCB’s Bimekizumab Abstract

UCB is ready to present bimekizumab’s results from BE MOBILE 1 for non-radiographic axial spondyloarthritis (nr-axSpA), BE MOBILE 2 for ankylosing spondylitis (AS), and BE COMPELTE study for psoriatic arthritis (PsA).


This year, the EULAR (European Congress of Rheumatology) 2022 will be held virtually and in-pace in Copenhagen, which will be providing the first-ever hybrid congress experience. Among the access presentations planned for EULAR 2022, we have chosen something of supreme importance.


Bimekizumab is a humanized monoclonal IgG1 antibody that is planned for particular and directly inhibiting interleukin 17A (IL-17A) and interleukin 17F (IL-17F) and other two key cytokines driving inflammatory processes.


UCB will be presenting data for evaluating bimekizumab in treating active nr-axSpA and AS from the two Phase III studies, BE MOBILE 1 and BE MOBILE 2. Bimekizumab showed maintenance of clinical response over three years in patients with active AS, according to the data from the open-label extension of the Phase IIb BE AGILE study, and the same data will be presented at the EULAR conference this year.


Patients who were treated with bimekizumab (160 mg every four weeks ) achieved analytically significant and clinically relevant improvements in the signs and symptoms of axSpA in BE MOBILE 1 and BE MOBILE 2. For PsA, Bimekizumab is in Phase III clinical development, which will be used to treat active psoriatic arthritis within a 24-week interval, as per the analysis from the OPTIMAL study, and a 16-week analysis from the BE COMPLETE is to be presented at the EULAR 2022 conference.


Conclusion


For the treatment of ankylosing spondylitis, Bimekizumab is the first humanized monoclonal IgG1. The competitors of Bimekizumab in the AS space are - Abbvie’s Rinvoq (upadacitinib), Eli Lilly’s Taltz (ixekizumab), and Pfizer Xelijanz (tofacitinib), among others.


For more detailed information visit: https://www.delveinsight.com/eular-conference/eular-2022

 

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