CAS No:112970-44-2
Formula:C7H8NOBr
Synonyms:2-Bromo-3-methoxyaniline;2-bromo-3-methoxybenzenamine;BenzenaMine, 2-broMo-3-Methoxy-;3-AMino-2-broMoanisole[2-BroMo-3-Methoxyaniline];2-Bromo-3-methoxy-phenylamine;SA021377
China Export:From 2018.11 to 2019.11, total export volume of 2-BROMO-3-AMINOANISOLE from China was 53,606,848KG while total export value was $325,443,345. The biggest proportion of exporting volume in the last 12 months was 11.96% in 2019.05.
Chemical 2-BROMO-3-AMINOANISOLE Basic Attributes
CAS No：112970-44-2
Molecular Formula ：C7H8NOBr
Molecular Mass ：202.05
Exact Mass ：200.978912
PSA ：35.2 A^2
LogP ：1.9
InChIKeys ：TUNIZJPEKHLBPR-UHFFFAOYSA-N
H-bond Acceptor ：2
H-bond Donor ：1
SP3 ：0.14
RBN ：1
Chemical 2-BROMO-3-AMINOANISOLE Characteristics
Density ：1.531±0.06 g/cm3(Predicted)
Bolling Point ：273.1±20.0 °C(Predicted)
Flash Point ：118.9±21.8 °C
Refractive Index ：1.596
Chemical 2-BROMO-3-AMINOANISOLE Safety Information
HS Code ：2922299090
Chemical 2-BROMO-3-AMINOANISOLE Production Methods
Step 1.Iron powder (1.08 mol) and ammonium chloride (862 mmol) were added to a solution of the bromide (216 mmol) in ethanol (200 mL) and water (140 mL) and the reaction mixture was heated at reflux for 1 h. To a suspension of 2-bromo-1-methoxy-3-nitrobenzene (3.90 g, 16.81 mmol) and iron powder (2.82 g, 50.4 mmol) in EtOH (50 mL) was added concentrated HC1 (3.08 mL, 37.0 mmol). The mixture was heated at 85 °C for 2.0 h. HPLC indicated a completion of the reaction. After cooled to room temperature, the solvent was removed under vacuum. The residue was suspended in EtOAc and saturated sodium bicarbonate.The insoluble material was removed by filtration through a pad of wet celite. The organic layer of the filtrate was collected, washed with brine, dried over sodium sulfate. After evaporation of solvent, Intermediate iSA (3.25 g, 16.09 mmol, 96 percentyield) was obtained as brown oil. It was used for the next step without further purification. ‘H NMR (500MHz, chloroform-d) 7.08 (t, J=8.1 Hz, 1H), 6.45 (dd, J8.0, 1.4 Hz, 1H), 6.34 (dd, J=8.3, 1.1 Hz, 1H), 3.89 (s, 2H); LC-MS: method A, RT = 1.21 mm, MS (ESI) m/z: 202.0 and 204.0 (M+H)2-bromo-1-methoxy-3-nitrobenzene (1 g, 4.31 mmol), Fe (1.68 g, 30.17 mmol) and NH4Cl (1.61 g, 30.17 mmol)were dissolved in THF (4 mL)/MeOH (4 mL)/H2O (2 mL) solution and stirred for 1 hour under reflux. After terminationof the reaction, the reaction solution was cooled to room temperature, diluted with saturated NaHCO3 solution andextracted with EtOAc. The extract solution was concentrated under reduced pressure and purified by column chromatography(eluent, EtOAc/Hex = 1/5) to obtain the title compound (0.83 g, 95 percent yield).1H NMR (500 MHz, CDCl3) δ 7.05(dd, 1H), 6.42(d, 1H), 6.31(d, 1H), 3.86(s, 3H)2-Bromo-3-nitroanisole B3 (1.00 g; 4.31 MMOL) was dissolved in glacial acetic acid (11.0 mL) and ethanol (11.0 mL). To this solution was added iron powder (0.98 g; 17.5 MMOL). The mixture was stirred at reflux for 3.5 h and worked up. The reaction mixture was diluted with water (35 mL), neutralized with solid Na2CO3 and the product extracted with CH2CI2 (3X 50 mL). The extracts were dried (NA2SO4), filtered and CONCENTRATED IN VACUO to afford the crude product, 2-bromo-3 methoxyaniline B4 (91 percent; 0. 79 g) as a pale yellow oil. MS 201.8 (MH) + ; Homogeneity by HPLC (TFA) 220 nm: 95percent.Step C:; 2-Bromo-3-nitroanisole 1b3 (1.00 g; 4.31 mmol) was dissolved in glacialacetic acid (11.0 mL)/ethanol (11.0 mL) and to the solution was added iron powder(0.98 g; 17.5 mmol). The mixture was stirred at reflux for 3.5 hr and worked up. Thereaction mixture was diluted with water (35 mL), neutralized with solid Na2-Bromo-3-nitroanisole 1b3 (1.00 g; 4.31 mmol) was dissolved in glacial acetic acid (11.0 mL)/ethanol (11.0 mL) and to the solution was added iron powder (0.98 g; 17.5 mmol). 2-Bromo-3-nitroanisole 2b3 (1.00 g; 4.31 mmol) was dissolved in glacialacetic acid (11.0 mL )/ethanol (11.0 mL) and to the solution was added iron powder(0.98 g; 17.5 mmol). The mixture was stirred at reflux for 3.5 hr and worked up. Thereaction mixture was diluted with water (35 mL), neutralized with solid NaStep C; 2-Bromo-3-nitroanisole 2B3 (1.00 g; 4.31 mmol) was dissolved in glacial acetic acid (11.0 mL)/ethanol (11.0 mL) and to the solution was added iron powder (0.98 g; 17.5 mmol). The mixture was stirred at reflux for 3.5 h and worked up. The reaction mixture was diluted with water (35 mL), neutralized with solid NaA solution of 2-bromo-l-methoxy-3 -nitrobenzene (500 mg, 2.16 mmol) in CH
Surfactant componentsIn relation to the cleansing enterprise, surfactants are the maximum versatile components used to create optimized cleansing formulations.
Surfactants lessen the surface tension between liquids and the interfacial anxiety between a liquid and a solid.
This reduction ends in a boom in spreading and wetting capability, giving a good deal higher cleaning outcomes.Surfactants are most generally used as wetting agents inside the form of soaps and detergents for cleaning oil and dirt from a floor, however are also utilized in insolubilizing, dispersing, and foaming programs.How Do Surfactant components paintings?Surfactants are amphiphilic, meaning they've each hydrophobicity (water-repelling) and hydrophilic (soluble in water) residences.
Surfactants also can lower the surface anxiety of agricultural remedies in order that nutrients may be greater conveniently absorbed by the plant.Anionic and Nonionic Surfactant additivesThere are quite a few specific surfactant additives that might be applied for numerous motives.
it can, however, purpose skin irritations.Nonionic surfactants, which include Aqua-Cleen®, don't have any charge and are frequently discovered in food, laundry, dishwasher detergents as well as in degreasers and plenty of difficult surfaces cleaning applications.
they are less probably to shape cleaning soap scum in tough water and typically do now not purpose skin irritations.In maximum instances, cleaning and frame contacting products use a mixture of each surfactant kinds to balance the cleaning capability whilst lowering the opportunity of skin troubles.
